Symbol
Name
ID

Fas
Fas cell surface death receptor
MGI:95484

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Abnormal lymphocyte apoptosis

Decreased lymphocyte apoptosis

Increased circulating IgA level

Increased circulating IgE level

Decreased circulating IgG level

Increased circulating IgG level

Decreased circulating total IgM

Increased circulating IgM level

Decreased specific anti-polysaccharide antibody level

Increased circulating antibody level

Reduced delayed hypersensitivity

Abnormality of blood and blood-forming tissues

Abnormal bleeding

Bruising susceptibility

Bone marrow hypercellularity

Bone marrow hypocellularity

Reticulocytosis

Hemolytic anemia

Autoimmune hemolytic anemia

Coombs-positive hemolytic anemia

Iron deficiency anemia

Eosinophilia

Neutropenia in presence of anti-neutropil antibodies

Increased B cell count

Decreased proportion of CD4-positive helper T cells

Abnormal proportion of CD4-positive T cells

Abnormal proportion of CD8-positive T cells

Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells

Increased proportion of HLA DR+ T cells

Lymphocytosis

Lymphopenia

Leukocytosis

Leukopenia

Abnormal granulocyte morphology

Abnormal basophil morphology

Ph-positive acute lymphoblastic leukemia

Acute myeloid leukemia

Chronic myelogenous leukemia

Myeloproliferative disorder

Thrombocytopenia

Autoimmune thrombocytopenia

Thrombocytosis

Hodgkin lymphoma

Non-Hodgkin lymphoma

B-cell lymphoma

Burkitt lymphoma

T-cell lymphoma

Elevated erythrocyte sedimentation rate

Splenomegaly

Hepatosplenomegaly

Hypersplenism

Disease(s) Associated with FAS

acute myeloid leukemia

autoimmune lymphoproliferative syndrome

chronic myeloid leukemia

cystic fibrosis

pre-eclampsia

rheumatoid arthritis

systemic lupus erythematosus

Mouse Phenotypes

decreased B cell apoptosis

increased T cell apoptosis

decreased macrophage apoptosis

impaired leukocyte tethering or rolling

abnormal leukocyte adhesion

abnormal T cell proliferation

thymus cortex atrophy

abnormal thymus medulla morphology

increased thymus weight

enlarged thymus

thymus atrophy

abnormal thymus involution

enlarged spleen

increased spleen weight

abnormal B cell receptor editing

decreased immature B cell number

decreased transitional stage B cell number

increased immature B cell number

increased transitional stage B cell number

abnormal T cell differentiation

abnormal T cell clonal deletion

increased double-negative T cell number

increased double-positive T cell number

decreased eosinophil cell number

increased neutrophil cell number

increased dendritic cell number

decreased mature B cell number

decreased marginal zone B cell number

increased follicular B cell number

increased marginal zone B cell number

increased plasma cell number

decreased B cell number

increased B cell number

increased NK cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased gamma-delta T cell number

increased memory T cell number

decreased T cell number

decreased activated T cell number

increased activated T cell number

increased lymphocyte cell number

increased leukocyte cell number

abnormal leukocyte morphology

abnormal B cell morphology

abnormal marginal zone B cell morphology

abnormal T cell morphology

abnormal spleen morphology

spleen hypoplasia

decreased spleen germinal center number

abnormal spleen periarteriolar lymphoid sheath morphology

abnormal splenic cell ratio

increased splenocyte number

abnormal B cell activation

abnormal immunoglobulin level

increased IgA level

increased IgG1 level

increased IgG2a level

increased IgG2b level

increased IgG3 level

decreased IgG level

increased IgG level

increased IgM level

increased immunoglobulin level

abnormal NK cell physiology

abnormal T cell physiology

abnormal T-helper 2 physiology

abnormal cytotoxic T cell physiology

Availability

Mouse Genotype

Fas^lpr-cg/Fas^lpr-cg

Fas^lpr/Fas^lpr

Fas^m1Btlr/Fas^m1Btlr

Fas^m2Btlr/Fas^m2Btlr

Fas^tm1.1Cgn/Fas^tm1.1Cgn

Fas^tm1Dlo/Fas^tm1Dlo

Fas^tm1Osa/Fas^tm1Osa

Fas^lpr/Fas^tm1.1Cgn

Cd19^tm1(cre)Cgn/Cd19⁺
Fas^tm1Ach/Fas^tm1Ach (conditional)

Fas^tm1Ach/Fas^tm1Ach
Tg(Lck-cre)548Jxm/? (conditional)

Fas^tm1Ach/Fas^tm1Ach
Tg(GZMB-cre)1Jcb/? (conditional)

Fas^tm1Ach/Fas^tm1Ach
Tg(Itgax-cre,-EGFP)4097Ach/? (conditional)

Fas^tm1Cgn/Fas^tm1Cgn
Tg(Cd4-cre)1Cwi/0 (conditional)

Fas^tm1Cgn/Fas^tm1Cgn
Tg(Mx1-cre)1Cgn/0 (conditional)

Cd19^tm1(cre)Cgn/Cd19⁺
Fas^lpr/Fas^tm1Cgn (conditional)

Cd19^tm1(cre)Cgn/Cd19⁺
Fas^lpr/Fas^tm1Cgn
Tg(Cd4-cre)1Cwi/0 (conditional)

Fas^lpr/Fas^tm1Cgn
Tg(Cd4-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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